HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: H2A1A (Q96QV6)
Histone H2A type 1-A (H2A-clustered histone 1) (Histone H2A/r)
Gene: H2AC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	32929329, 24244333
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~ubiquitin
Common GO terms	GO:0005634 - nucleus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 131
+	Hs
		226333 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		H2A1_HUMAN (1-129): 1.32e-65: 196: 92.25
+	Hs
		227595 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		H2A2C_HUMAN (1-129): 1.72e-65: 196: 92.25
+	Hs
		474911 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		H2AX_HUMAN (1-131): 2.3e-64: 194: 85.93
+	Sc
		392250 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		H2A2_YEAST (16-129): 1.87e-59: 181: 78.95
+	Hs
		476233 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		H2A1A_HUMAN (1-131): 1.2e-69: 206: 100.00
+	Hs
		475912 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		H2A2A_HUMAN (1-129): 9.53e-66: 197: 92.25
+	Hs
		476271 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		H2A1J_HUMAN (1-127): 4.78e-66: 197: 93.70
+	Hs
		391519 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		H2A1B_HUMAN (1-129): 2.1e-65: 196: 91.47
+	Hs
		475833 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		H2A2C_HUMAN (1-129): 1.72e-65: 196: 92.25
+	Hs
		475312 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		H2AX_HUMAN (1-131): 2.3e-64: 194: 85.93
+	At
		1092092 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		H2A6_ARATH (1-127): 6.84e-61: 184: 71.09