HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: WRIP1 (Q96S55)
ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1)
Gene: WRNIP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~ubiquitin, ubiquitin~zf-WRNIP1_ubi
Common GO terms	GO:0005634 - nucleus GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 665
+	Hs
		1301758 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		WRIP1_HUMAN (1-665): 0: 642: 100.00
+	Hs
		476243 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		WRIP1_HUMAN (1-665): 0: 642: 100.00
+	Hs
		226700 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LONM_HUMAN (115-586): 4.84e-63: 227: 11.64
+	Hs
		226671 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RFC2_HUMAN (200-541): 1.91e-66: 224: 18.44
+	Hs
		226670 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RFC4_HUMAN (205-567): 5.71e-64: 217: 16.01
+	Hs
		226739 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RFC5_HUMAN (221-559): 2.63e-64: 217: 19.10
+	Hs
		226740 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RFC3_HUMAN (227-505): 2.05e-60: 207: 14.10
+	Sc
		477307 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		WRIP1_YEAST (124-654): 1.92e-119: 370: 38.12
+	Hs
		475409 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RFC2_HUMAN (200-541): 1.91e-66: 224: 18.44
+	Hs
		475441 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RFC5_HUMAN (221-559): 2.63e-64: 217: 19.10
+	Hs
		475442 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RFC3_HUMAN (227-505): 2.05e-60: 207: 14.10