HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PSMD1 (Q99460)
26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112)
Gene: PSMD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	35509820, 35256949, 23503661
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PC_rep~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 953
+	Hs
		476252 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	At
		221381 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSD1A_ARATH (1-950): 0: 1219: 48.81
+	At
		1092259 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSD1B_ARATH (1-950): 0: 1202: 48.70
+	Hs
		227341 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Sc
		477186 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		RPN2_YEAST (2-953): 0: 984: 40.26
+	Sp
		251843 UBI4P_SCHPO (1-76): 1.1e-29: 121: 31.58		RPN2_SCHPO (1-953): 0: 1042: 43.67
+	Hs
		475701 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	At
		1091720 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSD2B_ARATH (8-796): 0: 741: 17.37
+	At
		1092336 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSD2A_ARATH (8-796): 0: 738: 17.61
+	Sc
		477264 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		RPN1_YEAST (8-604): 4.59e-149: 468: 15.96