HitPredict - High confidence protein-protein interactions

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PARK7 (Q99497)
Parkinson disease protein 7 (Maillard deglycase) (Oncogene DJ1) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124)
Gene: PARK7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.723

Property	Details
Experiments	24242043, 35256949, 15525661, 17846173, 19229105
Identification Methods	affinity chromatography technology, enzymatic study, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001933 - negative regulation of protein phosphorylation GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005783 - endoplasmic reticulum and 20 others more... GO:0005829 - cytosol GO:0006979 - response to oxidative stress GO:0007005 - mitochondrion organization GO:0008344 - adult locomotory behavior GO:0010628 - positive regulation of gene expression GO:0010629 - negative regulation of gene expression GO:0019899 - enzyme binding GO:0019900 - kinase binding GO:0034599 - cellular response to oxidative stress GO:0043524 - negative regulation of neuron apoptotic process GO:0044877 - protein-containing complex binding GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0048471 - perinuclear region of cytoplasm GO:0050821 - protein stabilization GO:0051583 - dopamine uptake involved in synaptic transmission GO:0051881 - regulation of mitochondrial membrane potential GO:0098793 - presynapse GO:1902236 - negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1903377 - negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1990381 - ubiquitin-specific protease binding
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	465
Hs

1	189

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024