HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: DNJC2 (Q99543)
DnaJ homolog subfamily C member 2 (M-phase phosphoprotein 11) (Zuotin-related factor 1) [Cleaved into: DnaJ homolog subfamily C member 2, N-terminally processed]
Gene: DNAJC2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35509820
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030544 - Hsp70 protein binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 621
+	Hs
		228971 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DNJB4_HUMAN (87-437): 2.89e-76: 248: 15.72
+	Hs
		228188 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DNJA4_HUMAN (85-422): 1.12e-73: 243: 16.14
+	Hs
		226636 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DNJA1_HUMAN (85-441): 2.38e-73: 242: 14.60
+	Hs
		226562 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DNJB1_HUMAN (87-421): 3.2e-73: 240: 15.25
+	Hs
		226020 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DNJA2_HUMAN (86-476): 3.75e-69: 232: 11.55
+	Hs
		227662 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DJC21_HUMAN (89-486): 2.36e-43: 165: 19.43
+	Hs
		228336 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DNJA3_HUMAN (86-216): 5.54e-35: 140: 23.91
+	Hs
		476114 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DNJA4_HUMAN (85-422): 1.12e-73: 243: 16.14
+	Hs
		475389 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DNJA1_HUMAN (85-441): 2.38e-73: 242: 14.60
+	Hs
		475355 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DNJB1_HUMAN (87-421): 3.2e-73: 240: 15.25
+	Hs
		243272 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DNJA2_HUMAN (86-476): 3.75e-69: 232: 11.55
+	At
		67521 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		A8MR40_ARATH (88-361): 2.97e-43: 158: 14.23
+	Hs
		476189 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DNJA3_HUMAN (86-216): 5.54e-35: 140: 23.91