HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PAAF1 (Q9BRP4)
Proteasomal ATPase-associated factor 1 (Protein G-16) (WD repeat-containing protein 71)
Gene: PAAF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.50	0.533

Property	Details
Experiments	35256949, 23503661
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 392
+	Hs
		228612 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBL1R_HUMAN (4-353): 5.38e-76: 246: 11.75
+	Hs
		226765 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LIS1_HUMAN (130-391): 7.01e-70: 227: 18.06
+	Hs
		227099 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GBB2_HUMAN (64-350): 1.04e-69: 224: 22.56
+	Hs
		228745 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GBB4_HUMAN (65-350): 1.54e-68: 221: 22.64
+	Hs
		228276 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FBXW7_HUMAN (167-390): 5.39e-51: 183: 14.98
+	Hs
		226950 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		COPA_HUMAN (4-376): 1.15e-43: 164: 12.85
+	Hs
		227097 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GBB1_HUMAN (6-283): 1.85e-46: 164: 19.66
+	Hs
		227540 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TAF5_HUMAN (126-389): 5.01e-37: 144: 12.22
+	Hs
		209358 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PLRG1_HUMAN (269-390): 2.01e-20: 94.9: 14.84
+	Hs
		228868 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NLE1_HUMAN (305-390): 1.26e-18: 89.4: 15.56
+	Hs
		227292 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBL3_HUMAN (86-268): 2.46e-18: 89: 28.50
+	Hs
		227054 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR5_HUMAN (314-390): 8.57e-15: 76.6: 9.88
+	Hs
		229055 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PRP19_HUMAN (89-204): 4.23e-13: 72.4: 33.06
+	Hs
		1334930 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		GBB4_HUMAN (65-350): 1.54e-68: 221: 22.64
+	Hs
		228315 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SNR40_HUMAN (308-388): 1.67e-09: 60.6: 11.63
+	Hs
		863478 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		COPA_HUMAN (4-376): 1.15e-43: 164: 12.85
+	Hs
		1281514 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		FBXW7_HUMAN (167-390): 5.39e-51: 183: 14.98
+	Sc
		477239 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		TAF5_YEAST (126-391): 8.85e-57: 200: 17.59
+	Sc
		477393 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		COPA_YEAST (3-376): 1.92e-44: 166: 10.58
+	Hs
		1219356 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		SNR40_HUMAN (308-388): 1.67e-09: 60.6: 11.63