HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: MTA3 (Q9BTC8)
Metastasis-associated protein MTA3
Gene: MTA3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35509820
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0042826 - histone deacetylase binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 594
+	Hs
		227357 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MTA1_HUMAN (1-586): 0: 627: 69.14
+	Hs
		226103 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MTA2_HUMAN (1-584): 0: 611: 64.40
+	Hs
		228409 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TREF1_HUMAN (121-469): 4.89e-52: 194: 16.71
+	Hs
		226047 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NCOR1_HUMAN (267-577): 2.53e-09: 62.7: 11.54
+	Hs
		476650 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		NCOR2_HUMAN (53-566): 2.01e-95: 322: 14.10
+	Hs
		476549 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RCOR1_HUMAN (148-567): 3.74e-78: 257: 16.63