HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: WDR41 (Q9HAD4)
WD repeat-containing protein 41
Gene: WDR41

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0010506 - regulation of autophagy
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 459
+	Hs
		227054 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR5_HUMAN (168-458): 7.11e-56: 190: 16.39
+	Hs
		209358 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PLRG1_HUMAN (124-432): 2.23e-40: 153: 11.53
+	Hs
		226765 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LIS1_HUMAN (202-459): 2.31e-37: 143: 14.58
+	Hs
		228868 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NLE1_HUMAN (306-459): 3.19e-24: 106: 15.95
+	Hs
		229098 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FBW1A_HUMAN (275-437): 5.15e-24: 106: 17.96
+	Hs
		228315 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SNR40_HUMAN (309-459): 5.82e-22: 98.7: 18.75
+	Hs
		228276 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FBXW7_HUMAN (307-459): 1.06e-19: 94.1: 17.31
+	Hs
		229023 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FBW1B_HUMAN (221-431): 1.05e-13: 75.1: 19.36
+	Hs
		152845 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		APAF_HUMAN (21-159): 4.24e-09: 61.2: 23.94
+	Hs
		1219356 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		SNR40_HUMAN (309-459): 5.82e-22: 98.7: 18.75
+	Hs
		1377165 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		FBW1A_HUMAN (275-437): 5.15e-24: 106: 17.96
+	Hs
		1281514 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		FBXW7_HUMAN (307-459): 1.06e-19: 94.1: 17.31
+	Hs
		1356385 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		FBW1B_HUMAN (221-431): 1.05e-13: 75.1: 19.36
+	Hs
		475563 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		WDR5_HUMAN (168-458): 7.11e-56: 190: 16.39
+	Sc
		477281 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		MET30_YEAST (39-158): 6.52e-14: 75.8: 21.67
+	Sc
		431108 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		CDC4_YEAST (2-159): 2.69e-11: 67.7: 19.90
+	Hs
		476595 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FBW1A_HUMAN (275-437): 5.15e-24: 106: 17.96
+	Hs
		476181 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SNR40_HUMAN (309-459): 5.82e-22: 98.7: 18.75
+	Hs
		476151 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FBXW7_HUMAN (307-459): 1.06e-19: 94.1: 17.31
+	Hs
		476547 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FBW1B_HUMAN (221-431): 1.05e-13: 75.1: 19.36