HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PUF60 (Q9UHX1)
Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1)
Gene: PUF60

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.50	0.585

Property	Details
Experiments	35509820, 35987950, 35256949
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 559
+	Hs
		227450 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		228318 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP5_HUMAN (133-308): 3.43e-45: 165: 23.86
+	Hs
		227669 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PAP1M_HUMAN (128-301): 1.14e-19: 89.4: 29.31
+	Hs
		227642 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PAP1L_HUMAN (421-559): 9.16e-15: 79.2: 13.67
+	Hs
		228678 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP3_HUMAN (479-559): 6.17e-13: 73.4: 19.75
+	Hs
		227354 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP4_HUMAN (457-550): 1.89e-10: 65.7: 10.64
+	Hs
		226375 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64
+	Hs
		312605 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		475757 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		1031383 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		PABP4_HUMAN (457-550): 1.89e-10: 65.7: 10.64
+	Hs
		312462 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64
+	At
		983451 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PABP5_ARATH (221-557): 8.41e-16: 82.7: 10.39
+	At
		186465 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PABP4_ARATH (479-555): 1.69e-11: 68.8: 14.29
+	Hs
		475708 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PABP4_HUMAN (457-550): 1.89e-10: 65.7: 10.64
+	Hs
		475288 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64