HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: G3BP2 (Q9UN86)
Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)
Gene: G3BP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 482
+	Hs
		227352 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		227532 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SAFB1_HUMAN (141-482): 2.07e-42: 163: 16.43
+	Hs
		476566 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		G3BP2_HUMAN (1-482): 5.94e-108: 330: 100.00
+	Sc
		477395 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		BRE5_YEAST (9-419): 2.98e-56: 197: 15.59
+	Hs
		475707 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Zm
		44516 Q41754_MAIZE (1-76): 8.11e-30: 121: 31.58		A0A1D6Q2L8_MAIZE (6-475): 6.16e-65: 218: 23.80
+	At
		1091970 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		NTF2B_ARATH (3-134): 5.63e-39: 139: 29.10
+	Zm
		18719 C0P3C8_MAIZE (227-459): 4.54e-25: 106: 17.87		A0A1D6H7I7_MAIZE (328-450): 1.68e-13: 73.5: 26.02