HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.89 0.60 0.731

The method score is based on:

Property Details
Experiments 28430587, 12150907, 35987950, 35256949, 14532270, 32814053
Identification Methods affinity chromatography technology, pull down, proximity labelling technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0001664 - G protein-coupled receptor binding
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
and 22 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 465
Hs

1 303
+ Hs
+ Hs
+ Hs
+ Hs
+ Ce
+ Dm
+ Dm
+ Hs
+ Dm
+ Hs
+ Hs
+ Pf

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024