HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: CSN3 (Q9UNS2)
COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3)
Gene: COPS3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	35256949, 32814053
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 423
+	Hs
		198497 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSMD3_HUMAN (49-415): 3.19e-93: 292: 18.14
+	Hs
		227037 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CSN2_HUMAN (21-393): 1.28e-87: 275: 12.23
+	Hs
		121640 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSD11_HUMAN (20-385): 1.17e-81: 258: 14.63
+	Hs
		228529 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CSN4_HUMAN (1-397): 3.04e-62: 208: 15.87
+	Hs
		476573 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CSN3_HUMAN (1-423): 2.33e-144: 419: 100.00
+	At
		1092162 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSD3B_ARATH (17-414): 2.74e-102: 314: 16.67
+	At
		1092148 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSD3A_ARATH (17-414): 1.41e-100: 309: 15.91
+	Sc
		477298 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		RPN3_YEAST (115-416): 1.38e-66: 222: 18.69
+	Hs
		198528 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSMD3_HUMAN (49-415): 3.19e-93: 292: 18.14
+	Hs
		475555 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CSN2_HUMAN (21-393): 1.28e-87: 275: 12.23
+	Hs
		121666 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSD11_HUMAN (20-385): 1.17e-81: 258: 14.63
+	At
		1092149 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSD11_ARATH (30-385): 7.89e-72: 233: 14.53
+	Hs
		476293 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CSN4_HUMAN (1-397): 3.04e-62: 208: 15.87
+	Sc
		477496 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		RPN6_YEAST (113-393): 1.42e-14: 77.2: 13.54