HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: DYN3 (Q9UQ16)
Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin)
Gene: DNM3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0014069 - postsynaptic density GO:0048471 - perinuclear region of cytoplasm GO:0098793 - presynapse
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 869
+	Hs
		226885 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Hs
		128370 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DNM1L_HUMAN (6-750): 0: 788: 38.25
+	Hs
		225987 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		OPA1_HUMAN (7-660): 1.13e-158: 490: 19.02
+	Hs
		226502 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MX2_HUMAN (7-483): 3.8e-156: 476: 33.33
+	Sc
		477122 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		VPS1_YEAST (7-745): 0: 605: 34.31
+	Zm
		24691 A0A1D6IJX7_MAIZE (233-459): 1.19e-26: 116: 21.70		A0A1D6K8W1_MAIZE (210-524): 2.45e-116: 361: 26.42
+	At
		1091806 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		DRP1C_ARATH (409-747): 7.46e-36: 146: 14.04
+	At
		789595 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		DRP1A_ARATH (494-748): 2.14e-33: 138: 12.92
+	At
		1091743 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		DRP1B_ARATH (499-748): 8.51e-33: 137: 13.33
+	At
		1092063 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		DRP1E_ARATH (456-749): 1.11e-32: 136: 12.30