HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: VDAC3 (Q9Y277)
Voltage-dependent anion-selective channel protein 3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3)
Gene: VDAC3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	35256949, 23068103, 23060438, 23503661
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0007612 - learning
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 283
+	Hs
		226775 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		VDAC2_HUMAN (1-283): 1.43e-119: 345: 73.50
+	Hs
		226516 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		VDAC1_HUMAN (1-283): 2.25e-109: 319: 67.49
+	Hs
		226184 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TOM40_HUMAN (1-279): 8.82e-67: 213: 10.92
+	Hs
		476591 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		VDAC3_HUMAN (1-283): 6.1e-112: 326: 100.00
+	Hs
		475333 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		VDAC1_HUMAN (1-283): 2.25e-109: 319: 67.49
+	At
		1092039 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		VDAC2_ARATH (2-282): 2.51e-72: 225: 23.24