HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: SGT1 (Q9Y2Z0)
Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog)
Gene: SUGT1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35987950
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0005634 - nucleus GO:0005829 - cytosol GO:0031647 - regulation of protein stability GO:0051087 - protein-folding chaperone binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 365
+	Hs
		226943 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PPP5_HUMAN (9-242): 1.39e-38: 145: 14.71
+	Hs
		227343 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DNJC3_HUMAN (6-326): 2.67e-25: 108: 15.69
+	Hs
		174471 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		OGT1_HUMAN (48-303): 5e-18: 87.6: 9.51
+	Hs
		226108 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TOM70_HUMAN (3-221): 1.5e-09: 61.4: 9.29
+	Dm
		1180619 PRKN_DROME (1-463): 3.5e-106: 325: 42.19		Q7KJA9_DROME (2-163): 1.31e-22: 101: 14.82
+	Dm
		1214030 LUBEL_DROME (55-453): 1.14e-66: 234: 16.95		Q9VH81_DROME (4-218): 1.63e-39: 148: 13.58
+	Dm
		284375 ARI2_DROME (228-464): 7.29e-69: 229: 20.92		Q7KJA9_DROME (2-163): 1.31e-22: 101: 14.82
+	Hs
		174509 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		OGT1_HUMAN (48-303): 5e-18: 87.6: 9.51
+	Sc
		477102 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		STI1_YEAST (2-145): 1.79e-14: 76.4: 23.61
+	Hs
		213459 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SGTA_HUMAN (6-171): 3.42e-40: 146: 20.96
+	Hs
		475702 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DNJC3_HUMAN (6-326): 2.67e-25: 108: 15.69
+	Hs
		475662 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SPAG1_HUMAN (2-339): 1.63e-24: 107: 12.50
+	Pf
		1181548 Q7KQK2_PLAF7 (1-76): 8.17e-31: 124: 28.95		HSOP_PLAF7 (12-273): 3.32e-18: 88: 16.67
+	Hs
		174570 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		OGT1_HUMAN (48-303): 5e-18: 87.6: 9.51
+	Hs
		476163 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TTC28_HUMAN (7-112): 2.84e-13: 73.3: 26.36