HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: FBX7 (Q9Y3I1)
F-box only protein 7
Gene: FBXO7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 1.00 0.834

The method score is based on:

Property Details
Experiments 35509820, 23933751
Identification Methods affinity chromatography technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains F-box-like~ubiquitin
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0000422 - autophagy of mitochondrion
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
and 12 others

more...
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 465
Hs

1 522
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024