HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: M4K5 (Q9Y4K4)
Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5)
Gene: MAP4K5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 846
+	Hs
		227381 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KCC2D_HUMAN (8-517): 1.77e-144: 437: 18.38
+	Hs
		226582 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MARK3_HUMAN (13-559): 3.08e-135: 422: 18.71
+	Hs
		229082 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KCC2A_HUMAN (8-488): 3.27e-138: 420: 19.26
+	Hs
		226638 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT2_HUMAN (1-350): 8.02e-130: 398: 22.63
+	Hs
		227863 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MARK2_HUMAN (2-473): 3.58e-124: 394: 21.36
+	Hs
		226637 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT1_HUMAN (12-346): 6.18e-125: 386: 22.38
+	Hs
		227317 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		STK4_HUMAN (10-278): 1.36e-120: 375: 45.93
+	Hs
		228945 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		STK26_HUMAN (7-302): 4.07e-119: 368: 43.43
+	Hs
		226172 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		M4K4_HUMAN (2-295): 4.04e-64: 236: 43.51
+	Sc
		419769 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		SNF1_YEAST (7-561): 1.99e-132: 410: 17.35
+	Hs
		682055 RNF14_HUMAN (161-464): 6.69e-69: 229: 21.56		AKT1_HUMAN (12-346): 6.18e-125: 386: 22.38
+	Hs
		474936 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT2_HUMAN (1-350): 8.02e-130: 398: 22.63
+	Hs
		474935 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT1_HUMAN (12-346): 6.18e-125: 386: 22.38
+	Hs
		475012 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		STK4_HUMAN (10-278): 1.36e-120: 375: 45.93
+	Hs
		475723 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KCC2D_HUMAN (8-517): 1.77e-144: 437: 18.38
+	At
		1091641 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN10_ARATH (19-410): 1.94e-133: 409: 18.99
+	At
		1091642 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CDPKB_ARATH (4-387): 7.54e-134: 409: 20.05
+	At
		1091676 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CDPK3_ARATH (6-388): 1.94e-129: 399: 21.61
+	Hs
		475390 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AKT1_HUMAN (12-346): 6.18e-125: 386: 22.38