HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: MTCH2 (Q9Y6C9)
Mitochondrial carrier homolog 2 (Met-induced mitochondrial protein)
Gene: MTCH2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0070585 - protein localization to mitochondrion
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 303
+	Hs
		229010 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		S2513_HUMAN (100-302): 1.38e-37: 143: 16.91
+	Hs
		226379 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ADT3_HUMAN (113-299): 3.27e-29: 114: 14.00
+	Hs
		226250 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ADT2_HUMAN (113-299): 1.34e-28: 113: 13.50
+	Hs
		226378 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ADT1_HUMAN (113-299): 2e-28: 112: 13.78
+	Hs
		226076 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		S2512_HUMAN (4-115): 2e-18: 87.3: 14.29
+	Hs
		227774 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SCMC2_HUMAN (205-302): 1.84e-11: 66.1: 9.18
+	Hs
		227780 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SCMC1_HUMAN (209-301): 1.92e-11: 66.1: 10.75
+	Hs
		475260 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		MTCH2_HUMAN (1-303): 6.71e-85: 259: 100.00
+	Hs
		476482 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MTCH1_HUMAN (8-295): 1.79e-108: 322: 46.89
+	Hs
		476654 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MTCH2_HUMAN (1-303): 6.71e-85: 259: 100.00
+	Hs
		1317097 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		S2513_HUMAN (100-302): 1.38e-37: 143: 16.91
+	Hs
		476538 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		S2513_HUMAN (100-302): 1.38e-37: 143: 16.91
+	Hs
		476087 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		S2540_HUMAN (1-109): 2.67e-14: 74.2: 17.43