HitPredict

Interactor 1: SMCA5 (O60264)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H)
Gene: SMARCA5

Interactor 2: DNMT1 (P26358)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
Gene: DNMT1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15313181
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005721 - pericentric heterochromatin
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1052 Hs			1 1616
+	Hs
		641217 CHD4_HUMAN (14-945): 0: 769: 26.95		DNMT1_HUMAN (1-1616): 0: 1717: 100.00
+	Hs
		1018557 CHD3_HUMAN (8-1052): 0: 801: 26.23		PB1_HUMAN (42-1162): 0: 602: 15.37
+	Hs
		1199209 CHD7_HUMAN (9-1049): 0: 800: 25.86		PB1_HUMAN (42-1162): 0: 602: 15.37
+	Hs
		1059704 CHD4_HUMAN (14-945): 0: 769: 26.95		PB1_HUMAN (42-1162): 0: 602: 15.37
+	Hs
		1199201 CHD8_HUMAN (6-1031): 0: 758: 26.13		PB1_HUMAN (42-1162): 0: 602: 15.37
+	Mm
		1111945 SMCA4_MOUSE (63-936): 0: 725: 30.53		PB1_MOUSE (42-1162): 0: 606: 15.20
+	Mm
		101533 SMCA4_MOUSE (63-936): 0: 725: 30.53		F8VQD1_MOUSE (42-1162): 0: 600: 14.69
+	Hs
		847007 SMCA4_HUMAN (63-960): 0: 696: 29.09		PB1_HUMAN (42-1162): 0: 602: 15.37
+	Hs
		229513 SMCA5_HUMAN (19-1052): 0: 1097: 100.00		DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65
+	Hs
		229525 SMCA5_HUMAN (19-1052): 0: 1097: 100.00		SMC3_HUMAN (112-523): 4.15e-40: 164: 12.53
+	Hs
		846812 SMCA2_HUMAN (161-654): 4.23e-122: 411: 44.02		PB1_HUMAN (42-1162): 0: 602: 15.37
+	Mm
		101535 SMCA2_MOUSE (161-654): 2.44e-122: 411: 44.02		F8VQD1_MOUSE (42-1162): 0: 600: 14.69
+	Hs
		1018753 CHD3_HUMAN (8-1052): 0: 801: 26.23		SMC3_HUMAN (112-523): 4.15e-40: 164: 12.53
+	Hs
		1059917 CHD4_HUMAN (14-945): 0: 769: 26.95		DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65
+	Hs
		1059947 CHD4_HUMAN (14-945): 0: 769: 26.95		SMC3_HUMAN (112-523): 4.15e-40: 164: 12.53
+	Hs
		1336301 CHD8_HUMAN (6-1031): 0: 758: 26.13		DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65
+	Hs
		1059815 CHD4_HUMAN (14-945): 0: 769: 26.95		MINT_HUMAN (5-706): 1.98e-35: 150: 12.71
+	Dm
		332845 CHDM_DROME (4-931): 0: 713: 27.96		Q9VGW4_DROME (3-394): 3.24e-27: 123: 14.50
+	Dm
		631317 BRM_DROME (150-656): 4.81e-125: 420: 44.76		Q9VC36_DROME (243-1099): 4.48e-111: 391: 11.16