HitPredict

Interactor 1: SMCA5 (O60264)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H)
Gene: SMARCA5

Interactor 2: H4 (P62805)
Histone H4
Gene: H4C1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.899

Property	Details
Experiments	27248496, 30804502, 16917504, 11691835
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	CENP-T_C~Helicase_C, CENP-T_C~SNF2-rel_dom
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization GO:0006334 - nucleosome assembly
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1052 Hs			1 103
+	Dm
		950383 ISWI_DROME (47-1051): 0: 977: 71.15		H4_DROME (1-103): 4.51e-48: 150: 99.03
+	Sc
		356774 ISW2_YEAST (1-1052): 0: 848: 45.67		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Hs
		917182 CHD3_HUMAN (8-1052): 0: 801: 26.23		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		918062 CHD7_HUMAN (9-1049): 0: 800: 25.86		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Sc
		356424 ISW1_YEAST (2-1046): 0: 790: 43.78		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Hs
		917277 CHD4_HUMAN (14-945): 0: 769: 26.95		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917364 CHD9_HUMAN (15-1035): 0: 768: 25.96		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917635 CHD6_HUMAN (54-1045): 0: 759: 27.09		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917965 CHD8_HUMAN (6-1031): 0: 758: 26.13		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917533 CHD1L_HUMAN (175-867): 0: 711: 38.23		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		151483 CHD2_HUMAN (10-1037): 0: 705: 28.83		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		846914 SMCA4_HUMAN (63-960): 0: 696: 29.09		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Sc
		356248 SNF2_YEAST (23-767): 0: 711: 36.53		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Sc
		356350 CHD1_YEAST (107-975): 0: 688: 30.65		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Sp
		144535 HRP3_SCHPO (149-798): 8.46e-127: 421: 39.19		H4_SCHPO (18-103): 4.87e-42: 135: 89.54
+	Sc
		356344 STH1_YEAST (149-637): 1.94e-127: 422: 47.44		H4_YEAST (18-103): 6.13e-41: 132: 90.70