HitPredict

Interactor 1: JIP4 (O60271)
C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1)
Gene: SPAG9

Interactor 2: MK08 (P45983)
Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
Gene: MAPK8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12391307
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1321 Hs			1 427
+	Mm
		1123147 JIP4_MOUSE (1-1321): 0: 799: 96.52		MK08_MOUSE (1-381): 7.75e-152: 437: 99.48
+	Hs
		800848 JIP3_HUMAN (1-1321): 0: 731: 54.49		MK08_HUMAN (1-427): 6.2e-164: 469: 100.00
+	Hs
		864879 JIP3_HUMAN (1-1321): 0: 731: 54.49		MK10_HUMAN (1-427): 6.5e-163: 468: 90.16
+	Hs
		800962 JIP3_HUMAN (1-1321): 0: 731: 54.49		MK09_HUMAN (1-427): 5.18e-163: 467: 80.80
+	Hs
		229677 JIP4_HUMAN (1-1321): 0: 803: 100.00		MK14_HUMAN (4-365): 2.33e-130: 381: 46.03
+	Mm
		814047 JIP4_MOUSE (1-1321): 0: 799: 96.52		MK14_MOUSE (4-365): 9.55e-131: 382: 46.03
+	Mm
		1143154 JIP3_MOUSE (1-1321): 0: 704: 55.14		MK10_MOUSE (1-427): 5.84e-164: 470: 89.46
+	Mm
		1322366 JIP3_MOUSE (1-1321): 0: 704: 55.14		MK09_MOUSE (1-427): 1.29e-160: 460: 81.50
+	Mm
		1265205 JIP3_MOUSE (1-1321): 0: 704: 55.14		MK08_MOUSE (1-381): 7.75e-152: 437: 99.48
+	Hs
		229628 JIP4_HUMAN (1-1321): 0: 803: 100.00		MK01_HUMAN (20-359): 2.94e-84: 263: 42.98
+	Mm
		926440 JIP3_MOUSE (1-1321): 0: 704: 55.14		MK01_MOUSE (20-359): 2.95e-84: 263: 42.98
+	Ce
		712388 JIP_CAEEL (16-1316): 2.02e-147: 479: 31.57		JNK1_CAEEL (1-366): 1.19e-135: 398: 68.21
+	Hs
		528368 MYH6_HUMAN (358-966): 2.92e-21: 103: 9.02		CDK3_HUMAN (23-329): 8.57e-130: 378: 33.55
+	Hs
		960128 MYH2_HUMAN (365-1000): 1.6e-20: 101: 8.85		CDK3_HUMAN (23-329): 8.57e-130: 378: 33.55
+	Hs
		522604 MYH7_HUMAN (382-959): 3.66e-20: 99.9: 9.76		CDK3_HUMAN (23-329): 8.57e-130: 378: 33.55
+	Hs
		625176 MYH9_HUMAN (437-932): 1.04e-14: 81.8: 9.68		CDK2_HUMAN (23-329): 1.82e-136: 394: 33.23
+	Hs
		522542 MYH1_HUMAN (382-1000): 1.25e-18: 94.9: 9.44		CDK3_HUMAN (23-329): 8.57e-130: 378: 33.55
+	Hs
		625177 MYH10_HUMAN (500-978): 2.95e-13: 77.2: 8.75		CDK2_HUMAN (23-329): 1.82e-136: 394: 33.23
+	Hs
		960129 MYH13_HUMAN (432-974): 5.27e-12: 72.9: 9.39		CDK3_HUMAN (23-329): 8.57e-130: 378: 33.55
+	Rn
		926486 ROCK2_RAT (276-759): 2.08e-20: 100: 11.99		MK01_RAT (20-359): 2.95e-84: 263: 42.98