HitPredict

Interactor 1: KIF5C (O60282)
Kinesin heavy chain isoform 5C (EC 3.6.4.-) (Kinesin heavy chain neuron-specific 2) (Kinesin-1)
Gene: KIF5C

Interactor 2: TRAK2 (O60296)
Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein)
Gene: TRAK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

Property	Details
Experiments	15644324, 26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0032839 - dendrite cytoplasm GO:1904115 - axon cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 957 Hs			1 914
+	Hs
		230500 KIF5A_HUMAN (2-956): 5.34e-140: 446: 74.45		TRAK2_HUMAN (1-914): 1.13e-170: 521: 100.00
+	Rn
		1163333 KIF5A_RAT (2-956): 6.95e-138: 440: 73.72		TRAK2_RAT (1-914): 2.58e-159: 492: 86.56
+	Hs
		230481 KIF1B_HUMAN (5-747): 2.93e-109: 374: 23.29		TRAK2_HUMAN (1-914): 1.13e-170: 521: 100.00
+	Mm
		193275 KIF5A_MOUSE (2-956): 4.12e-138: 441: 74.14		HAP1_MOUSE (95-387): 1.41e-62: 225: 27.86
+	Hs
		855644 KIF11_HUMAN (8-866): 2.09e-162: 505: 27.69		DCTN1_HUMAN (101-551): 8.67e-12: 71.5: 14.47
+	Hs
		148562 KIF11_HUMAN (8-866): 2.09e-162: 505: 27.69		CTRO_HUMAN (296-586): 1.62e-11: 70.6: 9.62
+	Hs
		229894 KIF5C_HUMAN (1-957): 7.99e-130: 417: 100.00		HOOK1_HUMAN (62-391): 3.97e-36: 148: 18.21
+	Hs
		1017532 KIF5A_HUMAN (2-956): 5.34e-140: 446: 74.45		ITSN1_HUMAN (259-658): 1.38e-14: 80.7: 9.22
+	Hs
		231757 KIF1B_HUMAN (5-747): 2.93e-109: 374: 23.29		HOOK1_HUMAN (62-391): 3.97e-36: 148: 18.21
+	Hs
		1017567 KIF5A_HUMAN (2-956): 5.34e-140: 446: 74.45		TRAK1_HUMAN (1-237): 9.38e-12: 71: 8.79
+	Mm
		139885 KIF5A_MOUSE (2-956): 4.12e-138: 441: 74.14		DCTN1_MOUSE (101-404): 1.07e-11: 71.2: 17.20
+	Hs
		229863 KIF5C_HUMAN (1-957): 7.99e-130: 417: 100.00		ITSN1_HUMAN (259-658): 1.38e-14: 80.7: 9.22
+	Hs
		229896 KIF5C_HUMAN (1-957): 7.99e-130: 417: 100.00		TRAK1_HUMAN (1-237): 9.38e-12: 71: 8.79
+	Hs
		216984 KIF1C_HUMAN (5-707): 2.58e-95: 327: 23.49		HOOK1_HUMAN (62-391): 3.97e-36: 148: 18.21
+	Hs
		231597 KIF1B_HUMAN (5-747): 2.93e-109: 374: 23.29		HOOK3_HUMAN (62-402): 2.97e-17: 88.9: 16.25
+	Hs
		725033 KI13B_HUMAN (6-762): 9.83e-112: 381: 23.11		MYH9_HUMAN (10-470): 8.16e-10: 65.3: 9.07
+	Hs
		231518 KIF1B_HUMAN (5-747): 2.93e-109: 374: 23.29		DCTN1_HUMAN (101-551): 8.67e-12: 71.5: 14.47
+	Hs
		216943 KIF1C_HUMAN (5-707): 2.58e-95: 327: 23.49		HOOK3_HUMAN (62-402): 2.97e-17: 88.9: 16.25
+	Rn
		869341 KIF5C_RAT (591-957): 2.87e-12: 72.9: 12.50		HAP1_RAT (95-387): 1.58e-64: 231: 29.10
+	Dm
		566098 KINH_DROME (506-956): 6.11e-11: 68.7: 10.04		MILT_DROME (86-360): 2.25e-28: 125: 30.18