HitPredict

Interactor 1: NUAK1 (O60285)
NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1)
Gene: NUAK1

Interactor 2: PP12C (Q9BZL4)
Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85)
Gene: PPP1R12C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	32707033, 24785407
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 661 Hs			1 782
+	Hs
		1318219 NUAK2_HUMAN (1-661): 2.59e-148: 445: 49.92		PP12C_HUMAN (1-782): 1.36e-154: 471: 100.00
+	Hs
		225111 NUAK1_HUMAN (1-661): 0: 581: 100.00		MYPT2_HUMAN (353-782): 4.07e-27: 120: 21.69
+	Hs
		161260 NUAK1_HUMAN (1-661): 0: 581: 100.00		MYPT1_HUMAN (542-782): 1.47e-22: 105: 33.61
+	Hs
		647851 MARK3_HUMAN (4-658): 1.17e-156: 471: 27.09		DAPK1_HUMAN (9-225): 2.08e-35: 147: 22.75
+	Hs
		862065 MARK2_HUMAN (1-658): 9.28e-152: 460: 23.88		DAPK1_HUMAN (9-225): 2.08e-35: 147: 22.75
+	Hs
		862115 MARK1_HUMAN (4-658): 1.87e-140: 431: 24.32		DAPK1_HUMAN (9-225): 2.08e-35: 147: 22.75
+	Hs
		161449 NUAK2_HUMAN (1-661): 2.59e-148: 445: 49.92		MYPT1_HUMAN (542-782): 1.47e-22: 105: 33.61