HitPredict

Interactor 1: MGRN1 (O60291)
E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1)
Gene: MGRN1

Interactor 2: MEGF8 (Q7Z7M0)
Multiple epidermal growth factor-like domains protein 8 (Multiple EGF-like domains protein 8) (Epidermal growth factor-like protein 4) (EGF-like protein 4)
Gene: MEGF8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0016020 - membrane GO:0045879 - negative regulation of smoothened signaling pathway GO:0070062 - extracellular exosome
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 552 Hs			1 2845
+	Hs
		1193257 RN157_HUMAN (1-495): 0: 654: 58.57		MEGF8_HUMAN (1-2845): 0: 1114: 100.00
+	Hs
		230107 MGRN1_HUMAN (1-552): 0: 894: 100.00		ATRN_HUMAN (447-1260): 1.09e-13: 79.8: 12.56
+	Hs
		276947 RN157_HUMAN (1-495): 0: 654: 58.57		ATRN_HUMAN (447-1260): 1.09e-13: 79.8: 12.56
+	Hs
		1138787 RN157_HUMAN (1-495): 0: 654: 58.57		ATRN1_HUMAN (428-1246): 3.31e-11: 71.8: 12.69