HitPredict

Interactor 1: ZEB2 (O60315)
Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b)
Gene: ZEB2

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.687

Property	Details
Experiments	35271311, 34026424, 18182442, 26028330
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1214 Hs			1 488
+	Hs
		231236 ZEB2_HUMAN (1-1214): 7.66e-177: 556: 83.52		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177142 ZEB2_HUMAN (1-1214): 7.66e-177: 556: 83.52		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		1038377 ZN273_HUMAN (994-1173): 6.57e-46: 177: 16.53		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		936395 PRDM1_MOUSE (255-383): 7.2e-25: 114: 20.14		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		271780 PRDM1_HUMAN (174-302): 3.7e-22: 105: 19.38		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		741072 ZEB1_HUMAN (1102-1173): 1.05e-11: 71.8: 8.22		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1251257 ZN461_HUMAN (985-1073): 1e-09: 64.7: 35.96		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		271762 PRDM1_HUMAN (174-302): 3.7e-22: 105: 19.38		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		741048 ZEB1_HUMAN (1102-1173): 1.05e-11: 71.8: 8.22		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		599074 ZNF10_HUMAN (172-302): 2.95e-26: 117: 16.00		HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04