HitPredict

Interactor 1: PI51C (O60331)
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Type I phosphatidylinositol 4-phosphate 5-kinase gamma)
Gene: PIP5K1C

Interactor 2: TLN1 (Q9Y490)
Talin-1
Gene: TLN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.726

Property	Details
Experiments	26149501, 15738269, 35044719, 14691141, 27775029, 23572508
Identification Methods	affinity chromatography technology, unspecified method, fluorescence polarization spectroscopy, phage display
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0005925 - focal adhesion GO:0032587 - ruffle membrane and 1 others more... GO:0098609 - cell-cell adhesion
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 668 Hs			1 2541
+	Mm
		250490 PI51C_MOUSE (1-668): 0: 915: 91.64		TLN1_MOUSE (1-2541): 0: 1536: 98.74
+	Hs
		231406 PI51C_HUMAN (1-668): 0: 933: 100.00		TLN2_HUMAN (1-2541): 0: 1486: 76.10
+	Hs
		56597 PIPSL_HUMAN (43-523): 0: 637: 67.78		MERL_HUMAN (80-638): 1.03e-92: 316: 14.79
+	Hs
		1253133 PI42C_HUMAN (33-443): 1.04e-140: 419: 30.09		E41L3_HUMAN (78-1116): 3.01e-115: 397: 11.42
+	Hs
		817775 PI42A_HUMAN (55-443): 8.91e-141: 418: 28.61		E41L3_HUMAN (78-1116): 3.01e-115: 397: 11.42
+	Hs
		942454 PI42B_HUMAN (51-443): 1.21e-137: 411: 30.17		E41L3_HUMAN (78-1116): 3.01e-115: 397: 11.42
+	Hs
		1253122 PI42C_HUMAN (33-443): 1.04e-140: 419: 30.09		E41L5_HUMAN (50-684): 9.18e-98: 335: 13.72
+	Hs
		817755 PI42A_HUMAN (55-443): 8.91e-141: 418: 28.61		E41L5_HUMAN (50-684): 9.18e-98: 335: 13.72
+	Hs
		719558 PI42C_HUMAN (33-443): 1.04e-140: 419: 30.09		MERL_HUMAN (80-638): 1.03e-92: 316: 14.79