HitPredict

Interactor 1: KDM1A (O60341)
Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A)
Gene: KDM1A

Interactor 2: SNAI1 (O95863)
Zinc finger protein SNAI1 (Protein snail homolog 1) (Protein sna)
Gene: SNAI1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.745

Property	Details
Experiments	25639869, 20389281, 26186194, 33961781, 20562920, 23011797
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, competition binding
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0010718 - positive regulation of epithelial to mesenchymal transition GO:0043518 - negative regulation of DNA damage response, signal transduction by p53 class mediator
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 852 Hs			1 264
+	Hs
		232532 KDM1A_HUMAN (1-852): 0: 936: 100.00		ZNF71_HUMAN (26-263): 9.61e-105: 314: 22.76
+	Hs
		232489 KDM1A_HUMAN (1-852): 0: 936: 100.00		ZN436_HUMAN (89-263): 1.45e-77: 243: 27.32
+	Hs
		208760 KDM1A_HUMAN (1-852): 0: 936: 100.00		SNAI2_HUMAN (1-259): 3.14e-74: 229: 51.11
+	Hs
		232349 KDM1A_HUMAN (1-852): 0: 936: 100.00		ZFP28_HUMAN (3-157): 7.05e-55: 191: 9.38
+	Mm
		1169765 KDM1A_MOUSE (1-852): 0: 922: 97.30		ZKSC3_MOUSE (86-262): 4.3e-56: 190: 23.70
+	Hs
		232373 KDM1A_HUMAN (1-852): 0: 936: 100.00		ZN480_HUMAN (2-72): 2.12e-22: 97.8: 5.63
+	Hs
		232472 KDM1A_HUMAN (1-852): 0: 936: 100.00		ZSA5A_HUMAN (150-232): 5.53e-10: 61.2: 38.82
+	Hs
		312077 SMRC2_HUMAN (5-300): 1.17e-57: 216: 15.14		ZBT7A_HUMAN (146-263): 9.95e-22: 95.9: 39.67