HitPredict

Interactor 1: KDM1A (O60341)
Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A)
Gene: KDM1A

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	36634849, 26269332
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0019899 - enzyme binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 852 Hs			1 758
+	Hs
		152564 KDM1A_HUMAN (1-852): 0: 936: 100.00		KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55
+	Hs
		203190 KDM1A_HUMAN (1-852): 0: 936: 100.00		SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76
+	Mm
		1169769 KDM1A_MOUSE (1-852): 0: 922: 97.30		CIC_MOUSE (23-723): 2.27e-11: 69.7: 9.34
+	Hs
		496294 AOFA_HUMAN (271-846): 1.8e-124: 387: 18.15		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496355 AOFB_HUMAN (288-847): 8.85e-119: 371: 17.78		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		1056891 KDM1B_HUMAN (160-501): 1.3e-62: 228: 24.86		MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57
+	Hs
		1056901 SMRC2_HUMAN (5-300): 1.17e-57: 216: 15.14		MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57
+	Hs
		1056914 SMRC1_HUMAN (34-300): 1.41e-57: 216: 16.96		MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57
+	Hs
		1239571 KDM1B_HUMAN (160-501): 1.3e-62: 228: 24.86		KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91
+	Dm
		1370310 Q9VVK2_DROME (266-497): 4.67e-26: 114: 19.84		Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96