HitPredict

Interactor 1: KDM1A (O60341)
Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A)
Gene: KDM1A

Interactor 2: H32 (Q71DI3)
Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o)
Gene: H3C15

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	34079125, 17687328, 15620353
Identification Methods	proximity labelling technology, x-ray crystallography, enzymatic study
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	Amino_oxidase~Histone
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 852 Hs			1 136
+	Hs
		232094 KDM1A_HUMAN (1-852): 0: 936: 100.00		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		232190 KDM1A_HUMAN (1-852): 0: 936: 100.00		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32
+	Hs
		232104 KDM1A_HUMAN (1-852): 0: 936: 100.00		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Hs
		232248 KDM1A_HUMAN (1-852): 0: 936: 100.00		H3C_HUMAN (1-136): 8.83e-59: 179: 94.12
+	Dm
		356119 LSDA_DROME (35-844): 0: 747: 50.41		H3_DROME (1-136): 3.73e-61: 186: 100.00
+	Hs
		934992 KDM1B_HUMAN (160-501): 1.3e-62: 228: 24.86		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		1086222 KDM1B_HUMAN (160-501): 1.3e-62: 228: 24.86		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32
+	Hs
		952473 KDM1B_HUMAN (160-501): 1.3e-62: 228: 24.86		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Hs
		935012 SMRC2_HUMAN (5-300): 1.17e-57: 216: 15.14		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		935075 SMRC1_HUMAN (34-300): 1.41e-57: 216: 16.96		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		952485 SMRC2_HUMAN (5-300): 1.17e-57: 216: 15.14		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Hs
		952518 SMRC1_HUMAN (34-300): 1.41e-57: 216: 16.96		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Hs
		828334 SMRC1_HUMAN (34-300): 1.41e-57: 216: 16.96		CENPA_HUMAN (9-133): 2.85e-44: 143: 50.00