HitPredict

Interactor 1: KDM1A (O60341)
Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A)
Gene: KDM1A

Interactor 2: PF21A (Q96BD5)
PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80)
Gene: PHF21A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.750

Property	Details
Experiments	12032298, 34709266, 27173435, 15325272, 12493763, 34079125, 16140033, 16079794, 17687328, 26751641
Identification Methods	biochemical, proximity labelling technology, affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	association, physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003682 - chromatin binding GO:0005654 - nucleoplasm GO:1990391 - DNA repair complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 852 Hs			1 680
+	Mm
		1169606 KDM1A_MOUSE (1-852): 0: 922: 97.30		PF21A_MOUSE (1-680): 2.03e-104: 334: 93.18
+	Mm
		1145012 KDM1A_MOUSE (1-852): 0: 922: 97.30		TIF1A_MOUSE (2-647): 3.9e-78: 271: 13.80
+	Hs
		232572 KDM1A_HUMAN (1-852): 0: 936: 100.00		KDM5B_HUMAN (147-656): 5.55e-61: 224: 13.90
+	Mm
		1169717 KDM1A_MOUSE (1-852): 0: 922: 97.30		KDM5B_MOUSE (139-656): 9.66e-59: 217: 14.83
+	Mm
		1113374 KDM1A_MOUSE (1-852): 0: 922: 97.30		KDM5A_MOUSE (211-656): 6.11e-55: 205: 16.34
+	Hs
		232170 KDM1A_HUMAN (1-852): 0: 936: 100.00		CHD4_HUMAN (324-650): 1.2e-41: 165: 16.04
+	Hs
		232129 KDM1A_HUMAN (1-852): 0: 936: 100.00		CHD3_HUMAN (298-617): 4.98e-41: 163: 15.21
+	Mm
		1161068 KDM1A_MOUSE (1-852): 0: 922: 97.30		CHD4_MOUSE (324-650): 3.17e-41: 164: 16.04
+	Hs
		231945 KDM1A_HUMAN (1-852): 0: 936: 100.00		NSD2_HUMAN (77-547): 1.68e-36: 149: 11.77
+	Hs
		232415 KDM1A_HUMAN (1-852): 0: 936: 100.00		PF21B_HUMAN (190-668): 6.44e-36: 144: 25.30
+	Hs
		232442 KDM1A_HUMAN (1-852): 0: 936: 100.00		PHF12_HUMAN (462-541): 1.99e-13: 76: 31.71
+	Ce
		104632 KDM1A_CAEEL (182-831): 1.14e-174: 525: 27.60		LE418_CAEEL (296-652): 1.28e-44: 174: 16.67
+	Hs
		1251641 SMRC2_HUMAN (5-300): 1.17e-57: 216: 15.14		KDM5B_HUMAN (147-656): 5.55e-61: 224: 13.90
+	Hs
		782365 SMRC2_HUMAN (5-300): 1.17e-57: 216: 15.14		KDM5C_HUMAN (169-655): 3.08e-60: 221: 15.75
+	Hs
		1059749 SMRC2_HUMAN (5-300): 1.17e-57: 216: 15.14		CHD4_HUMAN (324-650): 1.2e-41: 165: 16.04
+	Hs
		1059775 SMRC1_HUMAN (34-300): 1.41e-57: 216: 16.96		CHD4_HUMAN (324-650): 1.2e-41: 165: 16.04
+	Hs
		1018598 SMRC2_HUMAN (5-300): 1.17e-57: 216: 15.14		CHD3_HUMAN (298-617): 4.98e-41: 163: 15.21
+	Hs
		1018623 SMRC1_HUMAN (34-300): 1.41e-57: 216: 16.96		CHD3_HUMAN (298-617): 4.98e-41: 163: 15.21