HitPredict

Interactor 1: KDM1A (O60341)
Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A)
Gene: KDM1A

Interactor 2: RCOR1 (Q9UKL0)
REST corepressor 1 (Protein CoREST)
Gene: RCOR1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.993

The method score is based on:

Property Details
Experiments 20389281, 12032298, 26226427, 11171972, 33961781, 18806873, 25228645, 34709266, 16956976, 11102443, 21602794, 27173435, 28667074, 24981860, 34079125, 32882276, 34050636, 34031383, 22399799, 16885027 and 10 others

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Identification Methods pull down, biochemical, affinity chromatography technology, proximity labelling technology, x-ray crystallography, molecular sieving, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Amino_oxidase~Myb_DNA-binding
Common GO terms GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005667 - transcription regulator complex
GO:0006357 - regulation of transcription by RNA polymerase II
and 3 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 852
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024