HitPredict

Interactor 1: PHLP1 (O60346)
PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)
Gene: PHLPP1

Interactor 2: FLNB (O75369)
Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)
Gene: FLNB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33397691
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1717 Hs			1 2602
+	Hs
		232780 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		FLNA_HUMAN (1-2602): 0: 2661: 69.59
+	Hs
		261275 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		FLNB_HUMAN (1-2602): 0: 2855: 100.00
+	Hs
		598160 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		FLNA_HUMAN (1-2602): 0: 2661: 69.59
+	Hs
		1052885 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		FLNC_HUMAN (6-2602): 0: 1470: 35.38
+	Hs
		521558 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		ACTN1_HUMAN (5-364): 3.89e-117: 397: 27.15
+	Hs
		211592 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		ACTN4_HUMAN (12-364): 9.99e-114: 388: 26.58
+	Hs
		521600 ERBIN_HUMAN (637-806): 2.73e-09: 64.3: 26.86		ACTN1_HUMAN (5-364): 3.89e-117: 397: 27.15
+	Hs
		725690 ERBIN_HUMAN (637-806): 2.73e-09: 64.3: 26.86		ACTN2_HUMAN (5-364): 2.6e-116: 395: 26.61