HitPredict

Interactor 1: PHLP1 (O60346)
PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)
Gene: PHLPP1

Interactor 2: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1717 Hs			1 189
+	Hs
		349737 SHOC2_HUMAN (628-1094): 2.39e-24: 112: 27.84		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		350693 SHOC2_HUMAN (628-1094): 2.39e-24: 112: 27.84		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		1070230 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Ce
		612369 SHOC2_CAEEL (639-1019): 2.04e-15: 83.6: 23.60		LET60_CAEEL (1-189): 1.63e-85: 251: 74.60
+	Hs
		349581 ERBIN_HUMAN (637-806): 2.73e-09: 64.3: 26.86		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		72911 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		B4DMN1_HUMAN (4-184): 1.07e-73: 224: 33.88
+	Hs
		348879 ERBIN_HUMAN (637-806): 2.73e-09: 64.3: 26.86		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		1130165 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		Q5U0I6_HUMAN (4-187): 7.4e-74: 222: 34.36
+	Hs
		918884 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		RAB1A_HUMAN (4-187): 7.4e-74: 222: 34.36
+	Hs
		1130572 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		RAB1B_HUMAN (4-187): 1.21e-73: 221: 32.47
+	Hs
		1119533 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		Q504R6_HUMAN (4-186): 2.49e-72: 220: 36.76
+	Hs
		914117 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88
+	Hs
		896632 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		RAB14_HUMAN (4-184): 3.77e-72: 218: 29.51
+	At
		955322 BRL2_ARATH (995-1354): 8.35e-17: 89.1: 11.93		RAB1C_ARATH (4-182): 3.31e-72: 218: 30.94
+	Ce
		136853 LAP1_CAEEL (899-1163): 8.57e-14: 78.6: 29.74		RB11A_CAEEL (4-188): 1.02e-71: 217: 30.50
+	Hs
		350468 ERBIN_HUMAN (637-806): 2.73e-09: 64.3: 26.86		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		897898 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		RAP1B_HUMAN (1-165): 1.02e-62: 193: 57.49
+	Hs
		914297 ERBIN_HUMAN (637-806): 2.73e-09: 64.3: 26.86		RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88
+	Sc
		350785 CYAA_YEAST (1016-1332): 5.9e-15: 83.3: 13.12		RAS2_YEAST (3-164): 2.5e-58: 187: 64.42
+	Hs
		1130404 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		RIT1_HUMAN (3-176): 8.94e-56: 177: 50.29