HitPredict

Interactor 1: PHLP1 (O60346)
PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)
Gene: PHLPP1

Interactor 2: KPCB (P05771)
Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)
Gene: PRKCB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.747

Property	Details
Experiments	18162466
Identification Methods	phosphatase assay, anti tag coimmunoprecipitation, cosedimentation
Interaction Type	dephosphorylation reaction, physical association

Property	Details
Interacting Pfam domains	LRR_6~Pkinase, C1_1~PH, PH~Pkinase, PP2C~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006915 - apoptotic process and 1 others more... GO:0007165 - signal transduction
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1717 Hs			1 671
+	Hs
		232791 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33
+	Hs
		232792 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		AKT2_HUMAN (237-665): 2.34e-159: 469: 37.87
+	Hs
		233019 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		AKT3_HUMAN (284-665): 4.8e-158: 465: 41.48
+	Hs
		232782 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		KS6B1_HUMAN (291-671): 1.04e-153: 456: 36.83
+	Hs
		408635 PHLP2_HUMAN (469-1717): 0: 884: 53.15		KPCB_HUMAN (1-671): 0: 774: 100.00
+	Hs
		681911 PHLP2_HUMAN (469-1717): 0: 884: 53.15		AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33
+	Hs
		682190 PHLP2_HUMAN (469-1717): 0: 884: 53.15		AKT2_HUMAN (237-665): 2.34e-159: 469: 37.87
+	Hs
		1172970 PHLP2_HUMAN (469-1717): 0: 884: 53.15		AKT3_HUMAN (284-665): 4.8e-158: 465: 41.48
+	Hs
		616717 PHLP2_HUMAN (469-1717): 0: 884: 53.15		KS6B1_HUMAN (291-671): 1.04e-153: 456: 36.83
+	Rn
		88885 D4A254_RAT (469-1717): 0: 869: 52.84		AKT1_RAT (239-665): 9.61e-160: 470: 37.10
+	Hs
		681889 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33
+	Hs
		682184 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		AKT2_HUMAN (237-665): 2.34e-159: 469: 37.87
+	Hs
		784024 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		KPCI_HUMAN (10-86): 4.39e-13: 74.3: 40.26
+	Hs
		983856 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		KPCZ_HUMAN (10-86): 4.47e-12: 71.2: 36.36
+	Hs
		784073 ERBIN_HUMAN (637-806): 2.73e-09: 64.3: 26.86		KPCI_HUMAN (10-86): 4.39e-13: 74.3: 40.26