HitPredict

Interactor 1: PHLP1 (O60346)
PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)
Gene: PHLPP1

Interactor 2: KS6B1 (P23443)
Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA)
Gene: RPS6KB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	21986499
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	LRR_6~Pkinase, PH~Pkinase, PP2C~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006915 - apoptotic process GO:0007165 - signal transduction
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1717 Hs			1 525
+	Hs
		232792 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		AKT2_HUMAN (3-416): 5.02e-151: 442: 38.66
+	Hs
		233019 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		AKT3_HUMAN (29-418): 7.25e-151: 442: 38.29
+	Hs
		232791 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		AKT1_HUMAN (34-418): 1.81e-150: 440: 39.90
+	Hs
		232762 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		KPCB_HUMAN (35-422): 2.03e-146: 437: 36.92
+	Hs
		616717 PHLP2_HUMAN (469-1717): 0: 884: 53.15		KS6B1_HUMAN (8-525): 0: 573: 100.00
+	Hs
		1172970 PHLP2_HUMAN (469-1717): 0: 884: 53.15		AKT3_HUMAN (29-418): 7.25e-151: 442: 38.29
+	Hs
		682190 PHLP2_HUMAN (469-1717): 0: 884: 53.15		AKT2_HUMAN (3-416): 5.02e-151: 442: 38.66
+	Hs
		681911 PHLP2_HUMAN (469-1717): 0: 884: 53.15		AKT1_HUMAN (34-418): 1.81e-150: 440: 39.90
+	Hs
		408635 PHLP2_HUMAN (469-1717): 0: 884: 53.15		KPCB_HUMAN (35-422): 2.03e-146: 437: 36.92
+	Rn
		88885 D4A254_RAT (469-1717): 0: 869: 52.84		AKT1_RAT (34-418): 1.52e-150: 441: 39.64
+	Hs
		1130690 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		KS6B2_HUMAN (48-504): 2.75e-168: 486: 68.49
+	Hs
		682184 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		AKT2_HUMAN (3-416): 5.02e-151: 442: 38.66
+	Hs
		681889 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		AKT1_HUMAN (34-418): 1.81e-150: 440: 39.90
+	Hs
		568694 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		KAPCA_HUMAN (80-397): 6.73e-143: 417: 36.79
+	Hs
		850667 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		KS6A3_HUMAN (3-405): 3.09e-104: 330: 24.04
+	Hs
		1073471 ERBIN_HUMAN (637-806): 2.73e-09: 64.3: 26.86		KS6A1_HUMAN (6-405): 2.39e-104: 330: 23.79