HitPredict

Interactor 1: PHLP1 (O60346)
PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)
Gene: PHLPP1

Interactor 2: 2AAA (P30153)
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)
Gene: PPP2R1A

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	27880917
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004722 - protein serine/threonine phosphatase activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0051898 - negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1717 Hs			1 589
+	Hs
		232746 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		SF3B1_HUMAN (12-589): 2.5e-28: 122: 13.20
+	Hs
		232952 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		GCN1_HUMAN (28-589): 5.37e-25: 112: 16.01
+	Hs
		66468 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		A8K3H8_HUMAN (1-589): 2.03e-166: 488: 99.83
+	Hs
		672154 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00
+	Hs
		268749 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		SF3B1_HUMAN (12-589): 2.5e-28: 122: 13.20
+	Hs
		91008 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		E1NZA1_HUMAN (28-589): 5.23e-25: 112: 16.01
+	Hs
		1130405 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		TNPO1_HUMAN (24-483): 2.91e-20: 97.2: 15.05