HitPredict

Interactor 1: PHLP1 (O60346)
PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)
Gene: PHLPP1

Interactor 2: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34638419
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1717 Hs			1 1319
+	Hs
		808157 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		1192270 SHOC2_HUMAN (628-1094): 2.39e-24: 112: 27.84		HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32
+	Hs
		1130263 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32
+	Hs
		1301441 ERBIN_HUMAN (637-806): 2.73e-09: 64.3: 26.86		WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86
+	Hs
		1130453 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42