HitPredict

Interactor 1: PHLP1 (O60346)
PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)
Gene: PHLPP1

Interactor 2: NEST (P48681)
Nestin
Gene: NES

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33397691
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1717 Hs			1 1621
+	Hs
		232764 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		K2C8_HUMAN (7-315): 1.79e-122: 395: 23.68
+	Hs
		232770 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		K2C7_HUMAN (7-321): 7.48e-118: 381: 24.70
+	Hs
		232794 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		MYH9_HUMAN (729-1459): 1.22e-24: 115: 10.48
+	Hs
		232766 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		NFL_HUMAN (7-323): 1.31e-18: 93.6: 27.95
+	Hs
		166088 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		SYNEM_HUMAN (6-311): 3.29e-17: 90.5: 33.97
+	Mm
		1160064 PHLP1_MOUSE (1-1717): 0: 1375: 86.09		NEST_MOUSE (1-1409): 2.88e-55: 215: 41.82
+	Hs
		409102 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		K2C8_HUMAN (7-315): 1.79e-122: 395: 23.68
+	Hs
		1130818 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		V9HWE1_HUMAN (8-343): 3.05e-118: 382: 28.32
+	Hs
		443567 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		VIME_HUMAN (8-343): 3.05e-118: 382: 28.32
+	Hs
		531584 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		K2C5_HUMAN (7-319): 3.83e-86: 296: 20.56
+	Hs
		380486 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		K2C6B_HUMAN (6-332): 2.95e-86: 295: 21.11
+	Hs
		3119 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		A0A0S2Z428_HUMAN (6-332): 1.03e-84: 291: 20.82
+	Hs
		1130283 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		K2C73_HUMAN (1-316): 8.32e-64: 229: 19.14
+	Hs
		72923 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		B4DN72_HUMAN (6-313): 1.48e-63: 227: 21.66
+	Hs
		1130714 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		MYH2_HUMAN (549-1583): 8.08e-33: 141: 9.95
+	Hs
		724862 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		MYH9_HUMAN (729-1459): 1.22e-24: 115: 10.48
+	Hs
		1061133 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		NUMA1_HUMAN (818-1473): 5.43e-19: 96.5: 10.02
+	Hs
		422196 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		NFL_HUMAN (7-323): 1.31e-18: 93.6: 27.95
+	Hs
		61511 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		A5YM63_HUMAN (8-333): 2.47e-14: 80.5: 26.21
+	Hs
		725175 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		MYH10_HUMAN (14-453): 1.66e-13: 78.4: 11.24