HitPredict

Interactor 1: PHLP1 (O60346)
PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)
Gene: PHLPP1

Interactor 2: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.671

Property	Details
Experiments	33961781, 27880917, 19615732
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1717 Hs			1 337
+	Hs
		153848 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Hs
		232859 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		232877 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		232963 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Hs
		1075423 PHLP2_HUMAN (469-1717): 0: 884: 53.15		NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00
+	Hs
		153932 PHLP2_HUMAN (469-1717): 0: 884: 53.15		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Hs
		1172965 PHLP2_HUMAN (469-1717): 0: 884: 53.15		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Dm
		677695 SCRIB_DROME (739-1116): 5.3e-16: 86.7: 28.29		DLG1_DROME (12-325): 4.79e-25: 108: 16.57
+	Hs
		1050066 LRC40_HUMAN (691-1141): 7.56e-25: 113: 25.00		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		2885 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		A0A0G2JPP5_HUMAN (4-185): 3.33e-13: 72.7: 18.37
+	Hs
		1130458 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Mm
		1143369 ERBIN_MOUSE (637-806): 2.38e-09: 64.7: 26.29		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Hs
		942375 LRRC1_HUMAN (896-1143): 8.91e-09: 62: 28.74		DLG4_HUMAN (106-233): 1.85e-14: 76.2: 21.48
+	Hs
		1021557 LRRC1_HUMAN (896-1143): 8.91e-09: 62: 28.74		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		1050046 LRRC1_HUMAN (896-1143): 8.91e-09: 62: 28.74		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		1296886 LRRC1_HUMAN (896-1143): 8.91e-09: 62: 28.74		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71