HitPredict

Interactor 1: PHLP1 (O60346)
PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)
Gene: PHLPP1

Interactor 2: WDR20 (Q8TBZ3)
WD repeat-containing protein 20 (Protein DMR)
Gene: WDR20

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.927

Property	Details
Experiments	33961781, 25216524, 27880917, 33397691, 19615732
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~WD40
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1717 Hs			1 569
+	Hs
		232856 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		DMWD_HUMAN (12-568): 4e-94: 303: 51.52
+	Hs
		1172962 PHLP2_HUMAN (469-1717): 0: 884: 53.15		WDR20_HUMAN (1-569): 1.7e-149: 443: 100.00
+	Hs
		997655 PHLP2_HUMAN (469-1717): 0: 884: 53.15		DMWD_HUMAN (12-568): 4e-94: 303: 51.52
+	Hs
		1130792 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		WSB1_HUMAN (129-463): 1.01e-60: 208: 18.57
+	Hs
		1281479 SHOC2_HUMAN (628-1094): 2.39e-24: 112: 27.84		FBXW7_HUMAN (12-285): 5.88e-28: 120: 9.03
+	Hs
		91649 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		E9KL35_HUMAN (65-386): 1.87e-31: 126: 15.43
+	Hs
		929498 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		RACK1_HUMAN (65-386): 1.87e-31: 126: 15.43
+	Hs
		1123899 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		Q59EL4_HUMAN (12-247): 7.23e-30: 125: 11.89
+	Hs
		792995 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		LIS1_HUMAN (339-559): 5.1e-28: 118: 8.57
+	Hs
		903286 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		WDR5_HUMAN (424-569): 1.97e-14: 76.6: 14.77