HitPredict

Interactor 1: PHLP1 (O60346)
PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)
Gene: PHLPP1

Interactor 2: AKT3 (Q9Y243)
RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2)
Gene: AKT3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17386267
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_6~Pkinase, PH~PH, PH~Pkinase, PP2C~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0007165 - signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1717 Hs			1 479
+	Hs
		232792 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		AKT2_HUMAN (1-479): 0: 561: 75.78
+	Hs
		232791 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		AKT1_HUMAN (1-477): 0: 558: 82.29
+	Hs
		232762 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		KPCB_HUMAN (13-476): 3.8e-149: 442: 36.94
+	Hs
		232782 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		KS6B1_HUMAN (89-477): 4.14e-149: 437: 38.68
+	Hs
		1172970 PHLP2_HUMAN (469-1717): 0: 884: 53.15		AKT3_HUMAN (1-479): 0: 589: 100.00
+	Hs
		682190 PHLP2_HUMAN (469-1717): 0: 884: 53.15		AKT2_HUMAN (1-479): 0: 561: 75.78
+	Hs
		681911 PHLP2_HUMAN (469-1717): 0: 884: 53.15		AKT1_HUMAN (1-477): 0: 558: 82.29
+	Rn
		88885 D4A254_RAT (469-1717): 0: 869: 52.84		AKT1_RAT (1-477): 0: 561: 81.88
+	Hs
		408635 PHLP2_HUMAN (469-1717): 0: 884: 53.15		KPCB_HUMAN (13-476): 3.8e-149: 442: 36.94
+	Hs
		616717 PHLP2_HUMAN (469-1717): 0: 884: 53.15		KS6B1_HUMAN (89-477): 4.14e-149: 437: 38.68
+	Hs
		682184 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		AKT2_HUMAN (1-479): 0: 561: 75.78
+	Hs
		681889 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		AKT1_HUMAN (1-477): 0: 558: 82.29
+	Hs
		1130690 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		KS6B2_HUMAN (105-477): 1.09e-148: 434: 40.05
+	Hs
		73280 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		B4E2L0_HUMAN (83-441): 5.7e-146: 424: 37.33
+	Hs
		850667 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		KS6A3_HUMAN (146-418): 7.07e-101: 320: 28.52
+	Hs
		784024 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		KPCI_HUMAN (118-473): 3.27e-101: 317: 43.94
+	Hs
		1073471 ERBIN_HUMAN (637-806): 2.73e-09: 64.3: 26.86		KS6A1_HUMAN (54-459): 5.85e-103: 325: 21.91
+	Hs
		784073 ERBIN_HUMAN (637-806): 2.73e-09: 64.3: 26.86		KPCI_HUMAN (118-473): 3.27e-101: 317: 43.94