HitPredict

Interactor 1: PHLP1 (O60346)
PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)
Gene: PHLPP1

Interactor 2: SGT1 (Q9Y2Z0)
Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog)
Gene: SUGT1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.736

Property	Details
Experiments	27880917, 24145035, 28696259, 33397691, 19615732, 23440515
Identification Methods	affinity chromatography technology, proximity labelling technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1717 Hs			1 365
+	Hs
		233003 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		Q9P1S2_HUMAN (28-187): 2e-55: 180: 95.63
+	Hs
		232821 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		PPP5_HUMAN (9-242): 1.39e-38: 145: 14.71
+	Hs
		232984 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		RPAP3_HUMAN (3-129): 5.92e-27: 114: 14.17
+	Hs
		1172971 PHLP2_HUMAN (469-1717): 0: 884: 53.15		SGT1_HUMAN (1-365): 2.37e-88: 272: 100.00
+	Hs
		1334127 LRC40_HUMAN (691-1141): 7.56e-25: 113: 25.00		SGT1_HUMAN (1-365): 2.37e-88: 272: 100.00
+	Hs
		1357816 SHOC2_HUMAN (628-1094): 2.39e-24: 112: 27.84		SGT1_HUMAN (1-365): 2.37e-88: 272: 100.00
+	Hs
		66537 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		A8K5T7_HUMAN (1-365): 1.97e-88: 272: 99.73
+	Hs
		1301469 ERBIN_HUMAN (637-806): 2.73e-09: 64.3: 26.86		SGT1_HUMAN (1-365): 2.37e-88: 272: 100.00
+	Hs
		1312326 LRRC1_HUMAN (896-1143): 8.91e-09: 62: 28.74		SGT1_HUMAN (1-365): 2.37e-88: 272: 100.00
+	Hs
		73181 LRC40_HUMAN (691-1141): 7.56e-25: 113: 25.00		B4DYC6_HUMAN (57-365): 4.31e-64: 207: 86.41
+	Hs
		73193 SHOC2_HUMAN (628-1094): 2.39e-24: 112: 27.84		B4DYC6_HUMAN (57-365): 4.31e-64: 207: 86.41
+	Dm
		1364726 SUR8_DROME (638-866): 3.65e-36: 149: 21.30		Q9VH81_DROME (4-218): 1.63e-39: 148: 13.58
+	Hs
		73173 LRRC1_HUMAN (896-1143): 8.91e-09: 62: 28.74		B4DYC6_HUMAN (57-365): 4.31e-64: 207: 86.41
+	Sc
		443957 CYAA_YEAST (1016-1332): 5.9e-15: 83.3: 13.12		SGT1_YEAST (12-365): 5.06e-48: 168: 24.87
+	Hs
		1130595 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		RPAP3_HUMAN (3-129): 5.92e-27: 114: 14.17
+	Hs
		858664 LRRC1_HUMAN (896-1143): 8.91e-09: 62: 28.74		PPP5_HUMAN (9-242): 1.39e-38: 145: 14.71
+	Hs
		175307 SHOC2_HUMAN (628-1094): 2.39e-24: 112: 27.84		OGT1_HUMAN (48-303): 5e-18: 87.6: 9.51
+	Hs
		174950 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		OGT1_HUMAN (48-303): 5e-18: 87.6: 9.51
+	Hs
		297066 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		TOM70_HUMAN (3-221): 1.5e-09: 61.4: 9.29