HitPredict

Interactor 1: HBP1 (O60381)
HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1)
Gene: HBP1

Interactor 2: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29911972, 15235594
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 514 Hs			1 482
+	Xl
		1193361 Q90ZB8_XENLA (336-508): 4.67e-34: 134: 20.11		Q7ZYT5_XENLA (1-482): 0: 693: 90.46
+	Hs
		1038645 CIC_HUMAN (407-512): 6.93e-40: 156: 33.62		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		883315 SOX8_HUMAN (336-512): 1.87e-41: 156: 22.91		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		1270390 CIC_HUMAN (407-512): 6.93e-40: 156: 33.62		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		727863 SOX6_HUMAN (385-510): 1.46e-36: 146: 30.60		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		727903 SOX6_HUMAN (385-510): 1.46e-36: 146: 30.60		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Mm
		140241 SOX2_MOUSE (402-511): 1.35e-33: 131: 31.82		HDAC1_MOUSE (1-482): 0: 672: 99.38
+	Mm
		140273 Q60I23_MOUSE (402-511): 1.32e-33: 131: 31.82		HDAC1_MOUSE (1-482): 0: 672: 99.38
+	Hs
		1038736 HM20A_HUMAN (335-513): 3.32e-32: 128: 17.68		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		818023 SOX2_HUMAN (403-511): 1.47e-32: 128: 28.44		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Mm
		818688 SOX2_MOUSE (402-511): 1.35e-33: 131: 31.82		HDAC2_MOUSE (1-478): 0: 664: 85.71
+	Mm
		936399 Q60I23_MOUSE (402-511): 1.32e-33: 131: 31.82		HDAC2_MOUSE (1-478): 0: 664: 85.71
+	Rn
		1118086 LEF1_RAT (364-508): 3.86e-30: 123: 22.76		HDAC1_RAT (1-482): 0: 671: 99.17
+	Hs
		1270459 HM20A_HUMAN (335-513): 3.32e-32: 128: 17.68		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		818314 SOX2_HUMAN (403-511): 1.47e-32: 128: 28.44		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		1038795 LEF1_HUMAN (364-508): 1.1e-30: 125: 23.45		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		177214 SOX6_HUMAN (385-510): 1.46e-36: 146: 30.60		HDAC3_HUMAN (9-434): 0: 574: 57.94
+	Hs
		177229 SOX2_HUMAN (403-511): 1.47e-32: 128: 28.44		HDAC3_HUMAN (9-434): 0: 574: 57.94
+	Mm
		1142019 Q60I23_MOUSE (402-511): 1.32e-33: 131: 31.82		Q9JM08_MOUSE (9-434): 0: 568: 57.71
+	Hs
		177269 SRY_HUMAN (375-514): 1.32e-31: 122: 20.71		HDAC3_HUMAN (9-434): 0: 574: 57.94