HitPredict

Interactor 1: PEPL (O60437)
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)
Gene: PPL

Interactor 2: DESM (P17661)
Desmin
Gene: DES

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005200 - structural constituent of cytoskeleton GO:0005829 - cytosol GO:0005882 - intermediate filament GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1756 Hs			1 470
+	Hs
		234175 PEPL_HUMAN (1-1756): 3.44e-127: 441: 100.00		VIME_HUMAN (28-469): 1.16e-150: 439: 62.19
+	Hs
		234174 PEPL_HUMAN (1-1756): 3.44e-127: 441: 100.00		K2C8_HUMAN (81-464): 2.16e-139: 410: 35.01
+	Mm
		589655 PEPL_MOUSE (1-1756): 6.37e-116: 408: 87.48		VIME_MOUSE (24-469): 4.42e-147: 429: 61.42
+	Hs
		443532 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		VIME_HUMAN (28-469): 1.16e-150: 439: 62.19
+	Hs
		409080 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		K2C8_HUMAN (81-464): 2.16e-139: 410: 35.01
+	Hs
		781898 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		PERI_HUMAN (12-470): 2.13e-134: 397: 59.14
+	Hs
		443504 SPTN1_HUMAN (4-1191): 1.92e-18: 94.9: 10.52		VIME_HUMAN (28-469): 1.16e-150: 439: 62.19
+	Hs
		408987 MYH1_HUMAN (1062-1756): 6.26e-27: 122: 12.25		K2C8_HUMAN (81-464): 2.16e-139: 410: 35.01
+	Mm
		677677 PLEC_MOUSE (2-1071): 1.05e-33: 145: 10.58		DESM_MOUSE (1-470): 5.76e-114: 345: 97.45
+	Hs
		1068542 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		AINX_HUMAN (12-427): 1.09e-95: 299: 49.76
+	Hs
		422398 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		NFM_HUMAN (100-417): 8.9e-78: 262: 46.42
+	Hs
		569077 SPTN1_HUMAN (4-1191): 1.92e-18: 94.9: 10.52		DESM_HUMAN (1-470): 3.6e-109: 333: 100.00
+	Hs
		821662 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		K2C6C_HUMAN (8-435): 1.02e-70: 236: 29.79
+	Hs
		422355 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		NFM_HUMAN (100-417): 8.9e-78: 262: 46.42
+	Hs
		422175 SPTN1_HUMAN (4-1191): 1.92e-18: 94.9: 10.52		NFL_HUMAN (87-418): 9.76e-89: 282: 53.89
+	Mm
		93542 DESP_MOUSE (1619-1753): 8.47e-14: 79.5: 31.62		NFL_MOUSE (87-418): 2.04e-88: 281: 54.33
+	Hs
		318809 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		K2C75_HUMAN (9-427): 1.91e-82: 266: 33.33
+	Hs
		1061108 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		K2C72_HUMAN (14-419): 4.48e-75: 246: 30.17
+	Hs
		359462 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		K2C6A_HUMAN (8-435): 2.74e-69: 232: 29.10
+	Hs
		580132 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		K2C4_HUMAN (2-427): 2.49e-65: 220: 30.39