HitPredict

Interactor 1: PEPL (O60437)
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)
Gene: PPL

Interactor 2: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.649

Property	Details
Experiments	18624398, 12244133
Identification Methods	two hybrid, affinity chromatography technology, pull down, coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1756 Hs			1 480
+	Mm
		682130 PEPL_MOUSE (1-1756): 6.37e-116: 408: 87.48		AKT1_MOUSE (1-480): 0: 587: 98.33
+	Hs
		681696 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		AKT1_HUMAN (1-480): 0: 586: 100.00
+	Hs
		551616 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		AKT1_HUMAN (1-480): 0: 586: 100.00
+	Hs
		681881 GRDN_HUMAN (1065-1598): 6.32e-11: 70.1: 23.13		AKT1_HUMAN (1-480): 0: 586: 100.00
+	Rn
		1144340 SPTN2_RAT (73-1679): 2.07e-14: 81.4: 11.42		AKT3_RAT (1-478): 0: 545: 82.29
+	Hs
		623875 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		KPCL_HUMAN (106-477): 7.05e-149: 442: 41.98
+	Hs
		724784 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		KPCE_HUMAN (53-474): 3.43e-146: 437: 39.77
+	Hs
		528359 MYH6_HUMAN (1-1003): 1.54e-38: 160: 9.09		KAPCB_HUMAN (138-445): 1.1e-143: 417: 42.86
+	Mm
		554901 MYH6_MOUSE (1-859): 2.62e-29: 130: 8.50		KPCE_MOUSE (53-474): 8.58e-146: 436: 39.53
+	Hs
		568567 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		KAPCA_HUMAN (138-445): 1.76e-144: 419: 42.53
+	Mm
		554927 MYH7_MOUSE (3-749): 4.82e-27: 123: 9.37		KPCE_MOUSE (53-474): 8.58e-146: 436: 39.53
+	Hs
		116964 MYH1_HUMAN (1062-1756): 6.26e-27: 122: 12.25		SGK1_HUMAN (104-478): 5.29e-146: 426: 44.97
+	Hs
		610795 MYH2_HUMAN (1-850): 2.72e-29: 130: 9.21		KAPCB_HUMAN (138-445): 1.1e-143: 417: 42.86
+	Hs
		522538 MYH1_HUMAN (1062-1756): 6.26e-27: 122: 12.25		KAPCB_HUMAN (138-445): 1.1e-143: 417: 42.86
+	Dm
		397193 MYSN_DROME (595-1444): 1e-10: 69.3: 22.10		KPC1_DROME (14-477): 1.79e-152: 451: 35.91
+	Hs
		610802 MYH4_HUMAN (1242-1756): 4.37e-20: 100: 12.93		KAPCB_HUMAN (138-445): 1.1e-143: 417: 42.86
+	Hs
		551672 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		KPCE_HUMAN (53-474): 3.43e-146: 437: 39.77
+	Hs
		568689 GRDN_HUMAN (1065-1598): 6.32e-11: 70.1: 23.13		KAPCA_HUMAN (138-445): 1.76e-144: 419: 42.53
+	Hs
		1071717 MACF1_HUMAN (498-1680): 1.71e-12: 75.4: 12.90		KS6A2_HUMAN (85-452): 6.82e-94: 301: 25.39