HitPredict

Interactor 1: PEPL (O60437)
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)
Gene: PPL

Interactor 2: MYOME (Q5VU43)
Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein)
Gene: PDE4DIP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1756 Hs			1 2346
+	Hs
		1068562 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		MYOME_HUMAN (1-2346): 0: 703: 100.00
+	Mm
		93534 E9Q512_MOUSE (428-1743): 6.38e-37: 155: 11.71		MYOME_MOUSE (1-2346): 2.71e-171: 585: 69.33
+	Hs
		1034577 GOGA4_HUMAN (2-1336): 6.16e-43: 175: 9.40		GOGB1_HUMAN (880-2332): 2.13e-37: 157: 10.38
+	Hs
		1034574 GOGA4_HUMAN (2-1336): 6.16e-43: 175: 9.40		GOGA4_HUMAN (1116-2321): 1.5e-33: 145: 9.39
+	Hs
		502933 MYH3_HUMAN (4-887): 4.28e-29: 129: 9.04		MYH4_HUMAN (1279-2334): 2.89e-32: 140: 9.95
+	Hs
		528356 MYH6_HUMAN (1-1003): 1.54e-38: 160: 9.09		MYH6_HUMAN (1376-2333): 1.06e-22: 109: 8.98
+	Hs
		528435 MYH8_HUMAN (1062-1756): 2.18e-28: 127: 12.11		MYH4_HUMAN (1279-2334): 2.89e-32: 140: 9.95
+	Hs
		1302322 CP250_HUMAN (1-1328): 4.6e-43: 175: 11.06		CK5P2_HUMAN (1-1501): 2.27e-17: 91.6: 8.90
+	Hs
		724994 CP250_HUMAN (1-1328): 4.6e-43: 175: 11.06		MYH9_HUMAN (1753-2327): 1.1e-12: 76.2: 11.23
+	Hs
		724839 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		MYH9_HUMAN (1753-2327): 1.1e-12: 76.2: 11.23
+	Hs
		725097 MYH11_HUMAN (1-836): 1.44e-34: 147: 9.73		MYH10_HUMAN (1099-2077): 1.03e-18: 96.2: 11.20
+	Hs
		724687 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		MYH10_HUMAN (1099-2077): 1.03e-18: 96.2: 11.20
+	Hs
		724976 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		CK5P2_HUMAN (1-1501): 2.27e-17: 91.6: 8.90
+	Hs
		828575 CENPE_HUMAN (723-1718): 1.85e-27: 124: 11.52		CENPF_HUMAN (1261-2312): 1.38e-21: 105: 10.69
+	Hs
		502901 MYH6_HUMAN (1-1003): 1.54e-38: 160: 9.09		MYH3_HUMAN (1-361): 4.36e-09: 64.2: 10.90
+	Hs
		724686 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		MYH9_HUMAN (1753-2327): 1.1e-12: 76.2: 11.23
+	Rn
		361106 MYH6_RAT (1-860): 1.23e-29: 131: 8.60		MYH6_RAT (810-1589): 4.31e-15: 84.2: 11.67
+	Hs
		528432 MYH8_HUMAN (1062-1756): 2.18e-28: 127: 12.11		MYH13_HUMAN (1243-2074): 3.08e-10: 68.1: 11.50