HitPredict

Interactor 1: PEPL (O60437)
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)
Gene: PPL

Interactor 2: K1C25 (Q7Z3Z0)
Keratin, type I cytoskeletal 25 (Cytokeratin-25) (CK-25) (Keratin-25) (K25) (Keratin-25A) (K25A) (Type I inner root sheath-specific keratin-K25irs1)
Gene: KRT25

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005198 - structural molecule activity GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1756 Hs			1 450
+	Hs
		359355 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		K1C14_HUMAN (77-447): 2.09e-144: 422: 53.64
+	Hs
		724787 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		K1C17_HUMAN (72-441): 8.27e-144: 419: 52.70
+	Hs
		445052 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		K1C16_HUMAN (75-409): 9.44e-118: 354: 59.40
+	Hs
		444372 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		K1C19_HUMAN (73-391): 1.7e-110: 333: 56.43
+	Hs
		551676 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		K1C17_HUMAN (72-441): 8.27e-144: 419: 52.70
+	Hs
		164607 SPTN2_HUMAN (73-1521): 7.79e-13: 76.4: 12.03		K1C17_HUMAN (72-441): 8.27e-144: 419: 52.70
+	Hs
		974058 DYST_HUMAN (724-1629): 8.16e-09: 63.1: 11.55		K1C17_HUMAN (72-441): 8.27e-144: 419: 52.70
+	Hs
		522534 MYH1_HUMAN (1062-1756): 6.26e-27: 122: 12.25		K1C13_HUMAN (67-392): 5.06e-113: 341: 57.06
+	Hs
		49550 MYH1_HUMAN (1062-1756): 6.26e-27: 122: 12.25		A1A4E9_HUMAN (67-392): 1.26e-112: 340: 56.75
+	Hs
		1189645 CP250_HUMAN (1-1328): 4.6e-43: 175: 11.06		K1C27_HUMAN (1-447): 1.28e-77: 250: 80.75
+	Hs
		821662 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		K2C6C_HUMAN (44-413): 5.1e-78: 254: 21.02
+	Hs
		444307 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		K1C19_HUMAN (73-391): 1.7e-110: 333: 56.43
+	Hs
		318809 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		K2C75_HUMAN (2-408): 2.02e-91: 289: 23.53
+	Hs
		1061108 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		K2C72_HUMAN (2-397): 9.21e-85: 270: 21.41
+	Hs
		531529 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		K2C5_HUMAN (44-397): 2.98e-78: 256: 22.54
+	Hs
		359462 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		K2C6A_HUMAN (44-413): 1.21e-76: 251: 21.02