HitPredict

Interactor 1: PEPL (O60437)
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)
Gene: PPL

Interactor 2: WDTC1 (Q8N5D0)
WD and tetratricopeptide repeats protein 1
Gene: WDTC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37689310
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1756 Hs			1 677
+	Hs
		234241 PEPL_HUMAN (1-1756): 3.44e-127: 441: 100.00		WDR5B_HUMAN (536-664): 1.93e-19: 91.8: 15.39
+	Mm
		1132057 MYH4_MOUSE (1242-1756): 6.4e-22: 106: 12.74		WDTC1_MOUSE (1-677): 9.05e-131: 403: 93.66
+	Mm
		1112495 Q3UGX2_MOUSE (91-1661): 3.92e-18: 93.8: 11.40		WDTC1_MOUSE (1-677): 9.05e-131: 403: 93.66
+	Hs
		551777 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		WDTC1_HUMAN (1-677): 4.96e-133: 408: 100.00
+	Mm
		1194948 MY18A_MOUSE (465-1059): 5.4e-12: 73.5: 12.64		WDTC1_MOUSE (1-677): 9.05e-131: 403: 93.66
+	Hs
		725070 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		CHIP_HUMAN (357-493): 1.72e-38: 146: 30.66
+	Hs
		903240 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		WDR5_HUMAN (519-664): 4.67e-21: 96.8: 12.25
+	Hs
		551728 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		DCAF6_HUMAN (479-669): 8.52e-41: 161: 29.85
+	Hs
		792973 CENPE_HUMAN (723-1718): 1.85e-27: 124: 11.52		LIS1_HUMAN (486-675): 1.15e-24: 109: 11.00
+	Hs
		473599 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		DC8L2_HUMAN (237-677): 5.12e-36: 145: 16.74
+	Hs
		728492 MYH11_HUMAN (1-836): 1.44e-34: 147: 9.73		POC1A_HUMAN (3-74): 3.87e-12: 70.6: 18.06
+	Hs
		551738 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		DCAF8_HUMAN (511-677): 1.89e-31: 131: 29.15
+	Hs
		903212 SPTN1_HUMAN (4-1191): 1.92e-18: 94.9: 10.52		WDR5_HUMAN (519-664): 4.67e-21: 96.8: 12.25
+	Hs
		551632 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		LIS1_HUMAN (486-675): 1.15e-24: 109: 11.00
+	Hs
		903233 GOGB1_HUMAN (1144-1736): 3.26e-14: 81: 12.80		WDR5_HUMAN (519-664): 4.67e-21: 96.8: 12.25
+	Hs
		551655 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		WDR5_HUMAN (519-664): 4.67e-21: 96.8: 12.25
+	Hs
		903607 MACF1_HUMAN (498-1680): 1.71e-12: 75.4: 12.90		WDR5_HUMAN (519-664): 4.67e-21: 96.8: 12.25
+	Hs
		551766 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		WDR5B_HUMAN (536-664): 1.93e-19: 91.8: 15.39
+	Hs
		1061204 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		SNR40_HUMAN (5-71): 6.38e-13: 72.5: 22.39
+	Hs
		551854 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		NLE1_HUMAN (571-658): 2.46e-14: 77.9: 20.23