HitPredict

Interactor 1: PEPL (O60437)
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)
Gene: PPL

Interactor 2: FRMD1 (Q8N878)
FERM domain-containing protein 1
Gene: FRMD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005856 - cytoskeleton
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1756 Hs			1 549
+	Hs
		234184 PEPL_HUMAN (1-1756): 3.44e-127: 441: 100.00		EZRI_HUMAN (50-547): 1.13e-104: 328: 16.00
+	Hs
		640146 CP250_HUMAN (1-1328): 4.6e-43: 175: 11.06		MOES_HUMAN (50-531): 1.28e-91: 293: 15.67
+	Hs
		547271 MYH13_HUMAN (7-857): 7.73e-27: 122: 8.83		EZRI_HUMAN (50-547): 1.13e-104: 328: 16.00
+	Hs
		505568 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		EPB41_HUMAN (10-498): 2.19e-92: 303: 13.26
+	Hs
		640054 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		MOES_HUMAN (50-531): 1.28e-91: 293: 15.67
+	Hs
		505542 MYH1_HUMAN (1062-1756): 6.26e-27: 122: 12.25		EPB41_HUMAN (10-498): 2.19e-92: 303: 13.26
+	Hs
		547044 SPTN1_HUMAN (4-1191): 1.92e-18: 94.9: 10.52		EZRI_HUMAN (50-547): 1.13e-104: 328: 16.00
+	Hs
		1331065 MYH4_HUMAN (1242-1756): 4.37e-20: 100: 12.93		E41L1_HUMAN (3-458): 4.41e-99: 321: 16.57
+	Hs
		640092 CENPE_HUMAN (723-1718): 1.85e-27: 124: 11.52		MOES_HUMAN (50-531): 1.28e-91: 293: 15.67
+	Hs
		1061296 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		E41L3_HUMAN (7-543): 1.87e-99: 326: 12.77
+	Hs
		204667 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		E41L2_HUMAN (6-512): 1.41e-99: 325: 13.74
+	Hs
		547057 GOGB1_HUMAN (1144-1736): 3.26e-14: 81: 12.80		EZRI_HUMAN (50-547): 1.13e-104: 328: 16.00
+	Hs
		1061246 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		E41L1_HUMAN (3-458): 4.41e-99: 321: 16.57
+	Hs
		505631 SPTN1_HUMAN (4-1191): 1.92e-18: 94.9: 10.52		EPB41_HUMAN (10-498): 2.19e-92: 303: 13.26
+	Hs
		719709 SPTN1_HUMAN (4-1191): 1.92e-18: 94.9: 10.52		RADI_HUMAN (50-501): 4.75e-94: 300: 16.70
+	Hs
		1045531 SPTN1_HUMAN (4-1191): 1.92e-18: 94.9: 10.52		E41LA_HUMAN (51-549): 7.59e-91: 294: 14.21
+	Hs
		505634 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		EPB41_HUMAN (10-498): 2.19e-92: 303: 13.26
+	Hs
		640097 SPTN1_HUMAN (4-1191): 1.92e-18: 94.9: 10.52		MOES_HUMAN (50-531): 1.28e-91: 293: 15.67
+	Hs
		505537 SPTB1_HUMAN (189-1505): 5e-14: 80.3: 10.93		EPB41_HUMAN (10-498): 2.19e-92: 303: 13.26
+	Hs
		640102 GOGB1_HUMAN (1144-1736): 3.26e-14: 81: 12.80		MOES_HUMAN (50-531): 1.28e-91: 293: 15.67