HitPredict

Interactor 1: PEPL (O60437)
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)
Gene: PPL

Interactor 2: FYCO1 (Q9BQS8)
FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7)
Gene: FYCO1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1756 Hs			1 1478
+	Hs
		111569 K7EKI8_HUMAN (1-1756): 2.74e-125: 436: 99.77		FYCO1_HUMAN (1-1478): 4.9e-142: 475: 100.00
+	Hs
		148769 GOGA4_HUMAN (2-1336): 6.16e-43: 175: 9.40		CTRO_HUMAN (195-970): 2.82e-38: 159: 15.44
+	Hs
		148841 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		CTRO_HUMAN (195-970): 2.82e-38: 159: 15.44
+	Hs
		724994 CP250_HUMAN (1-1328): 4.6e-43: 175: 11.06		MYH9_HUMAN (1-843): 7.74e-35: 148: 11.32
+	Hs
		724839 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		MYH9_HUMAN (1-843): 7.74e-35: 148: 11.32
+	Hs
		528356 MYH6_HUMAN (1-1003): 1.54e-38: 160: 9.09		MYH6_HUMAN (435-1366): 9.43e-35: 148: 12.14
+	Hs
		148466 MYH11_HUMAN (1-836): 1.44e-34: 147: 9.73		CTRO_HUMAN (195-970): 2.82e-38: 159: 15.44
+	Hs
		148460 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		CTRO_HUMAN (195-970): 2.82e-38: 159: 15.44
+	Hs
		724686 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		MYH9_HUMAN (1-843): 7.74e-35: 148: 11.32
+	Rn
		361106 MYH6_RAT (1-860): 1.23e-29: 131: 8.60		MYH6_RAT (435-1366): 5.44e-35: 148: 12.14
+	Hs
		502901 MYH6_HUMAN (1-1003): 1.54e-38: 160: 9.09		MYH3_HUMAN (574-1269): 2.15e-25: 117: 11.79
+	Hs
		725097 MYH11_HUMAN (1-836): 1.44e-34: 147: 9.73		MYH10_HUMAN (1-594): 9.36e-27: 121: 12.67
+	Hs
		724687 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		MYH10_HUMAN (1-594): 9.36e-27: 121: 12.67
+	Hs
		502933 MYH3_HUMAN (4-887): 4.28e-29: 129: 9.04		MYH4_HUMAN (574-1306): 1.38e-26: 121: 11.92
+	Hs
		528435 MYH8_HUMAN (1062-1756): 2.18e-28: 127: 12.11		MYH4_HUMAN (574-1306): 1.38e-26: 121: 11.92
+	Hs
		1068536 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		PLEC_HUMAN (385-1169): 2.58e-09: 64.7: 22.38
+	Hs
		528432 MYH8_HUMAN (1062-1756): 2.18e-28: 127: 12.11		MYH13_HUMAN (718-1330): 1.28e-21: 104: 11.35
+	Mm
		93578 PLEC_MOUSE (2-1071): 1.05e-33: 145: 10.58		DESP_MOUSE (224-829): 7.47e-10: 66.2: 19.06